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EVIMED 60 mg Deus Medical: Een Effectieve Aromataseremmer

EVIMED 60 mg Deus Medical is een innovatieve aromataseremmer die vaak wordt gebruikt in de medische wereld. Aromataseremmers zijn essentieel voor de behandeling van verschillende hormonale aandoeningen, vooral bij vrouwen die worstelen met hormoonafhankelijke vormen van kanker. Dit medicijn helpt de oestrogeenproductie te blokkeren, waardoor het risico op groei van bepaalde tumorsoorten vermindert.

EVIMED 60 mg Deus Medical is een aromataseremmer die vaak wordt gebruikt in de medische wereld. Het is belangrijk voor mensen die op zoek zijn naar betrouwbare medicatie om hun gezondheid te ondersteunen. Voor meer informatie over dit product en om het te kopen, kunt u de volgende link bezoeken: EVIMED 60 mg Deus Medical kopen.

Wat zijn de Voordelen van EVIMED 60 mg?

  1. Vermindering van Oestrogeen: Door de werking van EVIMED wordt de oestrogeenproductie onder controle gehouden, wat belangrijk is voor bepaalde behandelingen.
  2. Effectieve Tumoronderdrukking: Het helpt bij het reduceren van de groei van hormoonafhankelijke tumoren, wat cruciaal is tijdens en na behandelingen.
  3. Verbeterde Levenskwaliteit: Patiënten rapporteren vaak een verbeterde levenskwaliteit door het effect van deze medicatie op hun gezondheid.

Gebruik en Dosering

Het gebruik van EVIMED 60 mg dient altijd in overleg met een arts te gebeuren. De gebruikelijke dosering kan variëren afhankelijk van de specifieke medische situatie van de patiënt. Het is belangrijk om de voorgeschreven dosis niet te overschrijden en regelmatig een controle afspraak te maken bij een zorgverlener.

Waar te Kopen?

Voor de meest betrouwbare aanschaf van EVIMED 60 mg Deus Medical kunt u de aanbevelingen volgen via de website die eerder genoemd is. Zorg ervoor dat u altijd koopt bij een erkende leverancier om de kwaliteit en effectiviteit van de medicatie te waarborgen.

EVIMED 60 mg Deus Medical biedt een waardevolle optie voor patiënten die een aanpak nodig hebben bij hormonale problemen. Overleg altijd met uw zorgverlener voor de juiste behandeling en zorg voor uw gezondheid.

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Peptide Cursus: Leer Over de Kracht van Peptiden

Wat zijn Peptiden?

Peptiden zijn korte ketens van aminozuren waarbij de verbindingen tussen de aminozuren peptidebindingen worden genoemd. Deze moleculen spelen een cruciale rol in verschillende biologische processen en worden steeds vaker onderzocht vanwege hun potentieel in de geneeskunde, sport en esthetische toepassingen.

Waarom een Peptide Cursus Volgen?

Als je geïnteresseerd bent in het leren over peptiden en hun toepassingen, is een peptide cursus een uitstekende keuze. Tijdens de cursus krijg je inzicht in de werking en voordelen van peptiden. Voor meer informatie en om peptiden aan te schaffen, kun je terecht op de pagina Peptide kopen.

Inhoud van de Peptide Cursus

Een peptide cursus behandelt doorgaans de volgende onderwerpen:

  1. De basisprincipes van peptiden en aminozuren.
  2. De biologische functies van peptiden in het lichaam.
  3. De verschillende soorten peptiden en hun toepassingen.
  4. Hoe peptiden worden geproduceerd en toegepast in de geneeskunde.
  5. De veiligheidsaspecten en bijwerkingen van peptidegebruik.

Voordelen van een Peptide Cursus

Door het volgen van een peptide cursus krijg je niet alleen theoretische kennis, maar ook praktische vaardigheden die je kunt toepassen in verschillende gebieden, zoals:

  • Sport en fitness: optimalisatie van prestaties.
  • Gezondheidszorg: behandelingen voor verschillende aandoeningen.
  • Esthetiek: huidverjonging en verbetering van de huidgezondheid.

Conclusie

Een peptide cursus biedt een uitstekende gelegenheid om jezelf te verdiepen in een onderwerp dat steeds relevanter wordt in onze moderne wereld. Of je nu een professional bent in de gezondheidszorg of gewoon nieuwsgierig bent naar de mogelijkheden van peptiden, deze cursus biedt waardevolle inzichten en kennis. Begin vandaag nog met het verkennen van de fascinerende wereld van peptiden!

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Estanozolol Instrucciones De Uso, Dosis Y Efectos Secundarios Del, Curso, Opiniones En Farmacia-deportivas

La administración con drogas hepatotóxicas puede aumentar el riesgo de daño hepático. El signo más evidente de una persona que abusa de esteroides es un incremento drástico o no pure de la masa muscular. Tanto los esteroides anabólicos como el alcohol están relacionados con problemas hepáticos, renales y cardíacos.

Combinación Con Otros Esteroides

Nunca olvide que siempre se debe integrar una terapia de ciclo de protección eficaz, es decir, utilizando NolvaGen (Nolvadex) o AnaGen (Arimidex). Lo que lo hace suave es el hecho de que puede ser utilizado con seguridad por hombres y mujeres por su ‘razonable’ efectos secundarios, que examinaremos con más profundidad más adelante en este artículo. Pero también ha demostrado ser un esteroide cuya eficacia tiene muy pocos productos comparables, especialmente cuando se trata de un artículo dedicado a mejorar el rendimiento del usuario. Los atletas profesionales destacan la eficaz interacción entre el estanozolol y la testosterona. Esta combinación cut back significativamente el riesgo de efectos secundarios y aumenta la eficacia del tratamiento con esteroides. Es un anab�lico sint�tico derivado de la testosterona; qu�micamente es el 17-a-hidroxi-17-b-metil androstano (3,2-c) pirazol, que posee efecto anabolizante y estimulante de la s�ntesis proteica.

¿qué Es Stanozoland 10 Mg?

  • El estanozolol se encuentra en las farmacias con el nombre de Winstrol y se vende solo con receta médica.
  • También es importante realizar chequeos regulares para evaluar la función hepática durante el tratamiento con estanozolol.
  • El estanozolol es un derivado modificado de la dihidrotestosterona (DHT) y por lo tanto de estrógenos no aromatizados a través de la clase de enzimas de la aromatasa.
  • Debido a esto, usualmente no es necesario para que coincida con un anti-estrógeno, tales como el nolvadex, ya que los efectos secundarios tales como la retención de la ginecomastia y el agua sólo afectan a las personas predispuestas.
  • Si determine consumir estas sustancias, recuerde que si va a utilizarlos combinados necesita utilizar una dosis inferior a la recomendada de cada uno.

Para los atletas de atletismo, una dosis óptima sería de 10 mg de estanozolol al día. También descubrió que el 90% del alcohol que consumen los adolescentes se utiliza en forma de consumo excesivo de alcohol. Acamprosato, ayuda a aliviar los síntomas a largo plazo, como la ansiedad y la depresión.

En cuanto a las estadísticas conocidas relacionadas con el consumo de esteroides, El Instituto Nacional sobre el Abuso de Drogas (NIDA) evidencia que las dosis autoadministradas pueden ser de 10 a one hundred veces una dosis recetada aceptable. Los hombres tienen 6 veces más probabilidades que las mujeres de utilizar dichos esteroides anabólicos. Además, se estima que 1 millón de hombres en Estados Unidos padecen dependencia de esteroides, según los Institutos Nacionales de Salud (INS).

Un aspecto a considerar es que la vida del estanozolol por vía inyectable y por vía oral no es la misma. A.D.A.M., Inc. está acreditado por URAC, también conocido como American Accreditation HealthCare Commission (). El programa de acreditación de URAC es una auditoría independiente para verificar que A.D.A.M. sigue rigurosos estándares de calidad y responsabilidad. A.D.A.M. es uno de los primeros en lograr esta distinción importante para la información y los servicios de salud en línea. Obtenga más información sobre la política editorial, el proceso editorial y la política de privacidad de A.D.A.M. A.D.A.M. es también miembro fundador de Hi-Ethics y se suscribe a los principios de Health on the Net Foundation ().

Precauciones Durante El Uso De Este Medicamento

El mecanismo estar�a relacionado con la disminuci�n de la concentraci�n del issue coagulante por aumento del catabolismo o defectos en su s�ntesis y un aumento de la afinidad del receptor por los anticoagulantes. Se recomienda reducir la dosis de anticoagulante para obtener el mismo efecto terap�utico. La administraci�n con drogas hepatot�xicas puede aumentar el riesgo de da�o hep�tico.

La calidad del sémen en los hombres disminuye con el empleo de Winstrol, y puede llegar a producir infertilidad. La supresión en la producción de testosterona en el hombre, especialmente si el ciclo de Winstrol se extiende más allá de 6 semanas es otro efecto bastante frecuente. Cuando veas a un culturista muy marcado y con la espalda o el pecho lleno de granos casi puedes apostar a que en ese momento está haciendo un ciclo que incluye winstrol. Depende de la sensibilidad de la persona que los use, de las cantidades y del tiempo durante el que se utilice. Mientras que por vía sus efectos en el organismo se prolongan por 24 horas, la forma oral sólo tiene una vida activa de 9 horas.

No lo use si usted tiene una enfermedad en los riñones llamada nefrosis o síndrome nefrótico. Las mujeres que no deben usar este medicamento son las que están embarazadas o las que tienen exceso de calcio (hipercalcemia) en la sangre y además cáncer de seno. Los hombres que no deben usar este medicamento son los que tienen cáncer de seno o de próstata. En términos de tiempo de detección en pruebas de dopaje, el estanozolol puede ser detectado en la orina hasta por varias semanas después de su uso, dependiendo de la dosis y la duración del ciclo. Por lo tanto, los atletas deben ser conscientes de este hecho al considerar su uso, ya que pueden ser sometidos a pruebas antidopaje en cualquier momento.

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ana­bo­lizan­tes onli­ne 27

Control De La Dispensación De Medicamentos Esteroides Anabolizantes Androgénicos

B) En aquellos hospitales de menos de cien camas que, en función de la tipología y volumen de actividad asistencial que implique una especial cualificación en el empleo de medicamentos, se determinen reglamentariamente. La dispensación se realizará por un farmacéutico, determinándose por la Consejería de Sanidad y Bienestar Social las existencias mínimas de especialidades farmacéuticas y productos sanitarios con los que debe contar. En el caso de cotitularidad, los farmacéuticos cotitulares podrán ejercitar el derecho de retracto authorized, en los términos previstos en la legislación civil, cuando se produzca la enajenación de una porción indivisa de una oficina de farmacia a favor de un tercero, que no ostente la cualidad de heredero. Cuando la oficina de farmacia cuente con secciones de análisis clínico, ortopedia especializada, óptica y/o acústica u otras actividades que pueda desarrollar el farmacéutico, contará con todos los requisitos adicionales que para estas actividades contemple la legislación al respecto, incluida la superficie adicional necesaria para cada sección o actividad diferenciada.

  • La testosterona está presente en la sangre en forma de testosterona libre (menos de un 4%) o testosterona unida (alrededor del 98%).
  • Si bien, la mayor gravedad de estos efectos aparecen con el uso a largo plazo de los agentes anabolizantes.
  • E) El incumplimiento de las funciones que, de acuerdo con la normativa vigente, tienen encargadas los diferentes centros de atención farmacéutica.
  • La hormona luteinizante recombinante y hCG requieren una administración inyectable varias veces a la semana y son caras.

¿cómo Puedo Obtener Un Certificado De Profesionalidad?

Se regulará reglamentariamente, de acuerdo con el volumen y diversidad de actividades de la oficina de farmacia, con su facturación, régimen horario y edad, el número mínimo de farmacéuticos adjuntos que deben prestar servicios en la misma. Será obligatorio disponer de un farmacéutico adjunto en aquellos casos cuyo titular haya cumplido más desixty five años y continúe al frente de la propiedad. Los establecimientos y servicios farmacéuticos de los distintos niveles, junto con los profesionales sanitarios, deberán actuar coordinadamente para ofrecer una atención farmacéutica integral a la población. Durante un largo período de tiempo, la dispensación de medicamentos ha sido asumido fundamentalmente por las oficinas de farmacia. Estos establecimientos sanitarios de interés público y titularidad privada han venido desempeñando una importante labor en la atención farmacéutica prestada a la población. A) La realización de estudios fármaco-epidemiológicos y de utilización de medicamentos, mediante el desarrollo de un sistema organizado de recogida y aprovechamiento de la información sobre prescripción y dispensación de medicamentos, disponibles para todos los profesionales sanitarios en las condiciones que se establezcan.

Cómo Comprar Esteroides En Línea

La epitestosterona es un isómero que se segrega conjuntamente con la testosterona y es inactiva. No hay conversión de testosterona a epitestosterona, y viceversa. El valor regular del índice testosterona/epitestosterona es comparable a 1/1. Un valor superior a 6/1 es indicativo de administración exógena. Podría enmascararse el resultado con la administración simultánea de epitestosterona. La implantación del pasaporte biológico en los atletas, instaurado en 2009 por la WADA, fue un paso importante en el management ya que garantiza la actualización de no haber consumido sustancias prohibidas63,sixty four.

Asimismo, las oficinas de farmacia deberán contar con los medios técnicos y materiales necesarios para el desarrollo de sus funciones. En los traslados provisionales con obligación de retorno, las distancias exigibles se podrán reducir a la mitad, salvo las relativas a los centros asistenciales que se determinen. Sólo se podrán autorizar traslados de oficinas de farmacia dentro de la misma zona farmacéutica y municipio. Para el cómputo de habitantes se tendrá en cuenta la población que conste en la última revisión del padrón municipal vigente en el momento de iniciarse el procedimiento de autorización. De acuerdo con los anteriores criterios de planificación y clasificación, por la Junta de Castilla y León se llevará a cabo la regulación reglamentaria de las distintas zonas farmacéuticas, cuyas delimitaciones y actualizaciones resultantes serán objeto de publicación por la Consejería de Sanidad y Bienestar Social.

Asimismo, las sanciones impuestas calificadas como leves, prescribirán al año; las calificadas como graves, a los dos años y las calificadas muy graves, a los cinco años. El plazo de prescripción de las sanciones empezará a contarse desde el momento en que la resolución imponiendo la sanción ponga fin a la vía administrativa. De conformidad con lo dispuesto en el artículo 37. 2 de la Ley 1/1993, de 6 de abril, de Ordenación del Sistema Sanitario de Castilla y León, también serán competentes para imponer sanciones los restantes órganos de la Administración de la Comunidad Autónoma para los que se hayan aprobado normas de desconcentración sobre competencias sancionadoras en materia sanitaria. K) La reincidencia en la comisión de infracciones graves en los últimos cinco años. B) El incumplimiento reiterado de los requerimientos específicos que formulen las autoridades sanitarias.

Algunos fármacos como los anticonvulsivantes, los barbitúricos y el clomifeno pueden aumentarla. En los hombres, el alcoholismo y la enfermedad hepática pueden producir una disminución de la concentración de testosterona. Algunos fármacos, como los andrógenos y los esteroides, también pueden producir una disminución de la testosterona. La testosterona está presente en la sangre en forma de testosterona libre (menos de un 4%) o testosterona unida (alrededor del 98%). La suma de la testosterona libre y la unida se puede medir en los laboratorios como testosterona whole.

Con ello se evitan los síntomas de deprivación16,49. El uso de agentes moduladores de estrógenos puede mantener la función eréctil tras la suspensión de la testosterona50. La administración de andrógenos suprime el eje hipotálamo-hipófiso-gonadal y, si es prolongada, el hipogonadismo resultante puede mantenerse meses y años después de haberse retirado el tratamiento45 con síntomas de disfunción eréctil y disminución de la libido46. Se produce atrofia de conductos seminíferos y disminución del tamaño testicular, lo que ocasiona una infertilidad con una disminución de hasta un 73% en el recuento de espermatozoides y cambios a veces irreversibles en la espermatogénesis47.

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a16z generative ai

Hippocratic AI raises $141M to staff hospitals with clinical AI agents

Story Partners with Stability AI to Empower Open-Source Innovation for Creators and Developers

a16z generative ai

Meanwhile, Kristina Dulaney, RN, PMH-C, the founder of Cherished Mom, an organization dedicated to solving maternal mental health challenges, helped to create an AI agent that’s focused on helping new mothers navigate such problems with postpartum mental health assessments and depression screening. The startup was initially focused on creating generative AI chatbots to support clinicians and other healthcare professionals, but has since switched its focus to patients themselves. Its most advanced models take advantage of the latest developments in AI agents, which are a form of AI that can perform more complex tasks while working unsupervised. Despite rapid advancements in AI, creators in open-source ecosystems face significant challenges in monetizing derivative works and securing proper attribution.

Story, the global intellectual property blockchain, has announced its integration with Stability AI’s state-of-the-art models to revolutionize open-source AI development. This collaboration enables creators, developers, and artists to capture the value they contribute to the AI ecosystem by leveraging blockchain technology to ensure proper attribution, tracking, and monetization of creative works generated through AI. Andreessen Horowitz, or a16z, is investing in AI and biotech to lead the way in innovation.

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In a statement, Raspberry AI said the funding would be used to accelerate its product development and add top engineering, sales and marketing talent to its team. But with U.S. companies raising and/or spending record sums on new AI infrastructure that many experts have noted depreciate rapidly (due to hardware/chip and software advancements), the question remains which vision of the future will win out in the end to become the dominant AI provider for the world. Or maybe it will always be a multiplicity of models each with a smaller market share? That’s followed by more extensive evaluations and safety assessments by an extensive network of more than 6,000 nurses and 300 doctors, who will confirm that it passes all required safety tests.

a16z generative ai

Once the AI agent is up and running, the clinicians who created it will be able to claim a share of the revenue it generates from the startup’s customers. Currently the technology is being used by Under Armour, MCM Worldwide, Gruppo Teddy and Li & Fung to create and iterate apparel, footwear and accessories styles. The company’s existing investors Greycroft, Correlation Ventures and MVP Ventures also joined in the round, along with notable angel investors, including Gokul Rajaram and Ken Pilot. Clearly, even as he espouses a commitment to open source AI, Zuck is not convinced that DeepSeek’s approach of optimizing for efficiency while leveraging far fewer GPUs than major labs is the right one for Meta, or for the future of AI.

Raspberry AI secures 24 million US dollars in funding round

Story is the world’s intellectual property blockchain, transforming IP into networks that transcend mediums and platforms, unleashing global creativity and liquidity. By integrating Stability AI’s advanced models, Story is taking a significant step toward building a fair and sustainable internet for creators and developers in the age of generative AI. Hippocratic AI said it’s necessary to have clinicians onboard because they have, over the course of their careers, developed deep expertise in their respective fields, as well as the practical insights to help cure specific medical conditions and the clinical workflows involved.

Investing in Raspberry AI – Andreessen Horowitz

Investing in Raspberry AI.

Posted: Mon, 13 Jan 2025 08:00:00 GMT [source]

Story aims to bridge this gap by combining Stability AI’s cutting-edge technology with blockchain’s ability to secure digital property rights. For example, creators could register unique styles or voices as intellectual property on Story with transparent usage terms. This would enable others to train and fine-tune AI models using this IP, ensuring that all contributors in the creative chain benefit when outputs are monetized.

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Holger Mueller of Constellation Research Inc. said Hippocratic AI is bringing two of the leading technology trends to the healthcare industry, namely no-code or low-code software development and AI agents. The launch is a bold step forward in healthcare innovation, giving clinicians the opportunity to participate in the design of AI agents that can address various aspects of patient care. It says clinicians can create an AI agent prototype that specializes in their area of focus in less than 30 minutes, and around three to four hours to develop one that can be tested. Shah said the last nine months since the company’s previous $50 million funding round have seen it make tremendous progress. During that time, it has received its first U.S. patents, fully evaluated and verified the safety of its first AI healthcare agents, and signed contracts with 23 health systems, payers and pharma clients.

a16z generative ai

For instance, one of its AI agents is specialized in chronic care management, medication checks and post-discharge follow-up regarding specific conditions such as kidney failure and congestive heart failure. The healthcare-focused artificial intelligence startup Hippocratic AI Inc. said today it has closed on a $141 million Series B funding round that brings its total amount raised to more than $278 million. “This round of financing will accelerate the development and deployment of the Hippocratic generative AI-driven super staffing and continue our quest to make healthcare abundance a reality,” he promised. Raspberry AI, the generative AI platform for fashion creatives, has secured 24 million US dollars in Series A funding led by Andreessen Horowitz (a16z). Today, we’re going in-depth on blockchain innovation with Robert Roose, an entrepreneur who’s on a mission to fix today’s broken monetary system. Hippocratic AI’s early customers include Arkos Health Inc., Belong Health Inc., Cincinnati Children’s, Fraser Health Authority (Canada), GuideHealth, Honor Health, Deca Dental Management, LLC, OhioHealth, WellSpan Health and other well-known healthcare systems and hospitals.

By incorporating this wisdom into its AI agents, it’s making them safer and improving patient outcomes, it said. Crucially, any agent created using its platform will undergo extensive safety training by both the creator and Hippocratic AI’s own staff. Every clinician will have access to a dashboard to track their AI agent’s performance and use and receive feedback for further development.

a16z generative ai

All these indicate the commitment a16z has in shaping the future of technology and healthcare through strategic investments. Both platforms use Stability AI’s models to bring creators’ visions to life and Story’s blockchain technology to enable provenance and attribution throughout the creative process. These real-world applications highlight how creators can safeguard their intellectual property while thriving in a shared creative economy. Raspberry AI offers brands and manufacturing creative teams technology solutions, which can help accelerate each stage of the fashion product development cycle to increase speed to market and profitability while reducing costs. Andreessen Horowitz, or a16z, is one of the leading AI investors and targets only innovative startups. They participated in the round that funded Anysphere on January 14, 2025, with a total sum of $105 million for an AI coding tool known as Cursor, whose valuation has reached $2.5 billion.

Onyxcoin (XCN) Market Trends and Ozak AI’s Contribution to AI-Driven Blockchain

In order to ensure its AI agents can do their jobs safely, Hippocratic AI says it only works with licensed clinicians to develop them, taking steps to verify their qualifications and experience first. Once clinicians have built their agents, they’ll be submitted to the startup for an initial round of testing. Through the Hippocratic AI Agent App Store, healthcare organizations and hospitals will be able to access a range of specialized AI agents for different aspects of medical care.

a16z generative ai

The startup was co-founded by Chief Executive Officer and serial entrepreneur Munjal Shah and a group of physicians, hospital administrators, healthcare professionals and AI researchers from organizations including El Camino Health LLC, Johns Hopkins University, Stanford University, Microsoft Corp., Google and Nvidia Corp. PIP Labs, an initial core contributor to the Story Network, is backed by investors including a16z crypto, Endeavor, and Polychain. Co-founded by a serial entrepreneur with a $440M exit and DeepMind’s youngest PM, PIP Labs boasts a veteran founding executive team with expertise in consumer tech, generative AI, and Web3 infrastructure. The startup has also created other AI agents for tasks like pre- and post-surgery wound care, extreme heat wave preparation, home health checks, diabetes screening and education, and many more besides. The startup said its AI Agent creators include Dr. Vanessa Dorismond MD, MA, MAS, a distinguished obstetrician and gynecologist at El Camino Women’s Medical Group and Teal Health, who helped to create an AI agent that’s focused on cervical cancer check-ins and enhancing patient education. According to the startup, the objective of these AI agents is to try and solve the massive shortage of trained nurses, social workers and nutritionists in the healthcare industry, both in the U.S. and globally.

TechBullion

The same day, a16z also led a Series A investment in Slingshot AI, which has raised a total of $40 million to create a foundation model for psychology. Those investments highlight the commitment of the group to using AI to address important issues and are also focusing on how AI can improve different industries, including healthcare and consumer services. In general, a16z is committed to supporting AI innovations that could have a profound impact on society. We are thrilled to see our models used in Story’s blockchain technology to ensure proper attribution and reward contributors,” said Scott Trowbridge, Vice President of Stability AI. Others include Kacie Spencer, DNP, RN, the chief nursing officer at Adtalem Global Education Inc., who has more than 20 years of experience in emergency nursing and clinical education. Her AI agent is focused on patient education for the proper installation of child car seats.

It participated in an Anysphere round that had the company raising $105 million on January 14, 2025, when it pushed the valuation up to $2.5 billion. Beyond this, it has also released a $500 million Biotech Ecosystem Venture Fund with Eli Lilly to place a focus on health technologies, but with the aspect of innovative applications. On the same day, they led a Series A investment in Slingshot AI, a company that’s developing advanced generative AI technology for mental health. Additionally, a16z invested in Raspberry AI to bring generative AI to the front of fashion design and production. In December 2024, they envisioned a future in which AI was used aggressively in nearly all sectors.

  • The startup said its AI Agent creators include Dr. Vanessa Dorismond MD, MA, MAS, a distinguished obstetrician and gynecologist at El Camino Women’s Medical Group and Teal Health, who helped to create an AI agent that’s focused on cervical cancer check-ins and enhancing patient education.
  • Andreessen Horowitz, or a16z, is one of the leading AI investors and targets only innovative startups.
  • Hippocratic AI said it’s necessary to have clinicians onboard because they have, over the course of their careers, developed deep expertise in their respective fields, as well as the practical insights to help cure specific medical conditions and the clinical workflows involved.
  • It says clinicians can create an AI agent prototype that specializes in their area of focus in less than 30 minutes, and around three to four hours to develop one that can be tested.
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Tobacco in Perfumes

Tobacco – A name that stirs up a not-so-good image with glances of cigarettes, smoke, and ashtrays. Apart from the idea of unpleasant smells, today we are going to know its real characteristics, which bewitch the perfumery world with its mysterious nuance rather than the contrasting reputation.

Tobacco, the common name of the plant Nicotiana tabacum is tropical in origin and has a long history that stretches back to 6,000 BC. Grown throughout the world, it is a member of the Nicotiana genus – a close relative to the poisonous nightshade and could previously only be found in the Americas. It was first said to be discovered by the native people of Mesoamerica and South America and later introduced to Europe and the rest of the world.

Nicholas Columbus was warmly greeted and welcomed by Native American tribes in 1492 when he first set his foot on the new continent. They gifted him with food, fruits, and many things, including dried-up leaves of the tobacco plant. However, Columbus soon realized that dried tobacco leaves are a prized possession among the natives, as they bartered with them and often bestowed them as a gift. Later, Rodrigo de Jerez and Luis de Torres, the first Europeans to observe smoking in Cuba, bring the habit back to Spain with Jerez as a staunch smoker.

In the 15th century, Portuguese sailors planted tobacco around nearly all their trading outposts, enough for therapeutic purposes, personal use, and gifts. It is in 1520 that tobacco seeds were imported to Europe. Jean Nicot, the French ambassador delivered dried leaves to the French queen, Catherine de Medici to relieve her migraines. This new “Queen’s herb” became famous and was given the name Nicotine in honor of Jean Nicot. By 1717, tobacco was popular and was cultivated and known by everyone. Gaining a strong foothold in the Revolutionary War of 1776, tobacco was used by the revolutionaries as collateral for the loans they were getting from France. The very first cigarettes were manufactured in the 1850s, making smoking widespread to all classes after the Second World War.

Tobacco has a long fibrous stem that can reach up to 1.5 meters in height, and produce white, yellow, or pink flowers with large hairy leaves. The leaves are harvested within three months and are hung on a rope to dry, making them change color from pale green to less dark brown, calling it Havana. Depending upon the variety and results, the drying process can take up to 4 to 10 weeks.

With the rise of niche perfumery, the fragrant characteristic of tobacco is needed from its absolute. By adding volatile solvents, the extract is taken from the leaves, creating a heavily dark-colored absolute with a rich smell. After diluting and decolorizing it, the tobacco extracts got their aroma, which is somewhat sweet, herbaceous, and woody, with notes of tea, and hay, besides hints of leather and chocolate.

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As it turns out, fresh tobacco pairs gorgeously with every fragrance family out there. It has a multi-faceted profile, bringing notes to the fragrances with a new spicy facet, between sweetness and bitterness. With its warm and quite soft notes, it can make a deeper dimension to woody composition or as a middle note to enrich as well as the base note for a long-lasting effect. The perfume of Tobacco is evoking, refined, and intense.

tobacco in perfume

As addictive as in cigars, the fragrance of tobacco in perfumery offers you an olfactory identity of familiar warmth and comfort with ZERO side effects…!

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White Flowers in Perfumes

Dating back to Victorian times, floriography let lovers express their feelings in different, more subtle ways. Different flowers hold different meanings and, in some cases, even the color can slightly alter the intent. White flowers are always favored for their refined image and elegance. Traditionally used in bridal bouquets or during memorial services, white flowers range in meaning from purity and innocence to sympathy. To relay these messages, the elegance & smell of these have been reserved for the wise, without self-denying. Growing all around the world, and unlike other floral nuances, they have a dual olfactory profile, between freshness and sensuality. Let us enjoy exploring this family further…

White Flowers have been an indispensable ingredient known to the world of perfumery for centuries. They have been starring in from the early classics and they continue to seduce everyone around until now. They are often perceived as olfactory representations of wild sensuality, extreme femineity, or even virginal purity. They also impart an olfactory versatility along with their carnal, sensual, and sometimes even heady, animal, or even narcotic scents. Almost all white flowers contain a natural compound called indole.

The white flower can exist in its natural form in perfumery. However, choosing flowers and composing a fragrance has a cost. Harvested by hand, white flowers are fragile that require precise know-how to extract their absolute.

Whatever the method used, the result is generally the same: an ultra-sensual, creamy, honeyed, sunny, and very deep scent. By choosing synthesis, perfumers can choose to focus on one facet rather than another.

A white floral heady fragrance is reminiscent of Jasmine and Tuberose.

Jasmine: Jasmine is a legendary emblematic, native to tropical and subtropical regions of Eurasia and Africa. There are more than 200 species of jasmine, out of which only two of them are particularly used in perfumes: the Grandiflorum and the Sambac. It is the most-favored white floral, with apparently, some 83 percent of fine fragrances including jasmine or jasmine-like notes, and around 33 percent of masculine fragrances incorporate its headiness too. The main producers are India and Egypt and on a small scale in France. Chemical solvent extraction is now the preferred methodology to obtain the absolute, which is the most widely used ingredient in perfumery and has long been called its King. The floral scent of jasmine is intoxicating, cloying, heavenly, heady, tenacious quite sweet, and fruity. It also has a musky smell. The combination of feminine sweetness and masculine wildness makes the smell of jasmine universally attractive. It gives richness and intensity to fragrances and helps to bring light and power depending upon its pairings.

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Tuberose: Tuberose is a star-shaped flower that has been used for centuries in perfumes. It is a perennial plant in the family Asparagaceae and was originally native to Mexico. Widely produced in India today, its scent is sweet and powdery with notes of musk, violet, and lily of the valley. Tuberose releases its essence by solvent extraction and offers a sulfurous scent between honeyed and candied nectar. It also has another aspect, greener, camphorated, and almost medicinal. We can also find milky accents with very sunny and orange notes, and a honeyed and almond side, like fruity jasmine. Its absolute releases a multitude of nuances to charm noses in search of originality and subtlety. It is a delicate, beautiful scent that will make you feel happy and cheerful.

White Flowers in Perfumes

With great richness, the fragrance of white flowers can be combined very easily with many accords. They are Romantic, sensual, and bewitching, and can highlight warm and oriental notes such as ambergrisvanilla, or tobacco. Perfumers can create bouquets of white flowers, which they usually position at the middle note of the fragrance to give it relief and with the ability to match each other very well.

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Sandalwood in Perfumes

Sandalwood has a sacred 4,000-year-old history of being mentioned in Sanskrit and Chinese manuscripts, making it one of the oldest fragrant ingredients used today. It is a class of woods from trees in the genus Santalum, where the woods are heavy, yellow, and fine-grained, and, unlike many other aromatic planks of wood, they retain their fragrance for decades. Sandalwoods are medium-sized hemiparasitic trees, about ten meters high with oval evergreen leaves and small odorless yellow flowers with purple shades. But neither its leaves nor its flowers make it so majestic, but its brown bark protects a pale green or white heart with a velvety scent. Sandalwood is native to Asia, and its main distribution is in the drier tropical regions of India and the Indonesian islands of Timor and Sumba. It produces a fleshy fruit: the drupe. Its pulp attracts birds, by consuming the fruit and then rejecting the seeds they contain, birds contribute to the natural spread of the species.

Its traces are found in Egypt in embalming practices. Buddhism and Hinduism consider it a sacred wood & used it during funeral ceremonies. In even more ancient times, it was used to build temples in Tibet, Nepal, and China. It is also used in the manufacture of incense and Ayurvedic medicine whereas even Chinese medicine also uses sandalwood essential oil to treat stomach aches and skin diseases. The appearance of sandalwood in Europe was later when the Arabs used it to perfume the leather of Cordoba in Spain.

The cradle of sandalwood is in India, in the state of Karnataka, where one of its most famous and coveted varieties can be found: Mysore sandalwood. At the end of the 18th century, the King of Mysore decreed sandalwood a royal monopoly, and India became the world’s leading sandalwood producer. In 1916, the Maharaja of Mysore created a government factory dedicated to sandalwood, later this quality became “the reference of Sandalwood Alba” with a worldwide reputation and will remain so throughout the 21st century. Highly prized, Mysore sandalwood perfume has long suffered from over-exploitation, which made the cutting prohibited from 2010. Today, it is also grown in other countries, including Australia and New Caledonia, in the Vanuatu archipelago. In Australia, the famous sandalnum album is cultivated on a large scale to compensate for the scarcity of sandalwood from India.

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Producing commercially valuable sandalwood with high levels of fragrance oils requires Indian sandalwood trees to be a minimum of 15 years old. The yield of oil tends to vary depending on the age and location of the tree; usually, the older trees yield the highest oil content and quality. The tree is usually cut down and uprooted, to be reduced to chips before being distilled. In the past, trees were felled, and then the branches and roots were cut down. The trunks were then left abandoned on the ground and fed to termites. Today, faced with the scarcity of sandalwood, all parts of the tree including roots are used, by reducing it to powder, which is later dried, and finally, steam distilled.

Oil is extracted from Sandalwood through distillation. Different methods are used, including steam distillation, water distillation, CO2 extraction, and solvent extraction. Steam distillation is the most common method used by sandalwood companies, which occurs in a four-step process, incorporating boiling, steaming, condensation, and separation. Water is heated to high temperatures and is then passed through the wood. The oil is very tightly bound within the cellular structure of the wood but can be released by the high heat of the steam. The mixture of steam and oil is then cooled and separated so that the essential oil can be collected. This process is much longer than any other oil distillation, taking 14 to 36 hours to complete, but generally produces much higher quality oil. Water, or hydro, distillation is the more traditional method of sandalwood extraction which involves soaking the wood in water and then boiling it until the oil is released. This method is not used as much anymore because of the high costs and time associated with heating large quantities of water.

Sandalwood contains 230 molecules, but not all of them are fragrant. Santalol, terpenes, beta-caryophyllene, Santa lines, bergamotol are the main components of sandalwood, and good quality sandalwood should contain at least 90% of santalol. Sandalwood became very rare, and it is the most expensive wood & fragrant raw material in the world. Its essence is often referred to as “liquid gold”, for which to obtain 45 liters of essential oil, about 1 ton of wood is needed, making it an endangered species.

Sandalwood in Perfumes

Due to the price & scarcity, of this jewel of perfumeryOrganic chemistry researchers created Sandela as a substitute molecule in 1947. During the 70s, Sandalore was used extensively to support natural sandalwood essence, and since then, discoveries have been made and other more powerful molecules such as Polysantol have been added to the formulas. Sandalwood oil has a distinctive earthy, warm, smooth, creamy precious-wood scent that provides perfumes with a striking aroma. When used in smaller proportions in a perfume, it acts as a fixative, enhancing the longevity of other, more volatile, materials in the composite & makes it a wonderful base note. The smell of sandalwood is categorized as a woody fragrance but it’s also earthy, with a sweet, fresh chypre odor.

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Amber in Perfumes

The term ‘Amber’ comes from the Arabic ‘Ambar’ or French ‘Ambre’ relating to Ambergris, a waxy substance found in the intestines of the sperm whale.! Amber is one of nature’s gems. True natural Amber takes millions of years to form, which is a long time.! You might have heard that amber comes from tree sap, but to be accurate it is created from resin. When a tree is injured, it releases a resin that seals the wound and hardens, protecting its trunks from the attacks of parasites and insects. These Resistant resins also heal every other internal damage, keeping the tree healthy and safe. Over time, the resin evolves as an organic Fossil and becomes hard Amber. One of the oldest forms of Amber is Baltic Amber and it dates to more than 40 million years. Amber is quite an interesting ingredient because it can contain creatures and plants from millions of years ago and has also been used since the stone age (13,000 years) ago in decorations and jewelry.

When the resin is secreted, it’s not certain that it will be turned into amber. That is because, more commonly, amber gets destroyed by adverse weather. First, the resin needs to be chemically stable and not degrade over time. It must be resistant to sun, rain, extreme temperatures, and microorganisms like bacteria and parasites. In addition to being resistant to adverse weather, the resin should also require proper conditions for fossilization. Amber, in its nascent stage, may be easily taken by the seawater after which it may be submerged deep under the various layers of sediments. This submerged amber will eventually fossilize.

In the Baltics, glaciers knocked down many trees and buried them, allowing them to fossilize. Wet clay and sand sediments preserve resin well because they don’t contain much oxygen and the sediments eventually transform into rocks. Persistent pressure and high temperature make the resin appear like orange gems. Young or copal amber is formed due to the polymerization of molecules and then the heat & pressure drive out terpenes which completes the amber transformation.

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There are two types of resin produced by plants that can fossilize. Terpenoids are produced by gymnosperms (conifers) and angiosperms. They are composed of ring structures made from isoprene (C5H8) units. Phenolic resins are only produced by Angiosperms. An uncommon tree known as Medullosans is known for producing a third unique kind of resin, which is, however, rarer. Most amber found is about 30-90 million years old, though it’s not sure how long the process to turn resin into amber takes. The oldest amber discovered is from the Upper Carboniferous, 320 million years ago. Most amber is from pine trees or other conifers, though there are a variety of trees that they can come from.

Amber is found in many places around the world, spanning from Alaska to Madagascar, with the largest deposits exploited for jewelry and science in the Dominican Republic, the Baltic region of Europe, and Myanmar, also known as Burma. With each region representing a different era of Earth’s geologic past, the youngest form of Amber is perhaps the Dominican amber which has a history of around 16 million to 25 million. Baltic amber, which like its Dominican counterpart typically includes ants, flies, and lizards, is 40 million years old; while the Burmese or Myanmar amber can be traced back to 100 million years, and it is probably the oldest amber known to man.

The most popular type of amber, Baltic amber was already exhausted by the 1800s. It is, however, assumed that several thousand tons of amber are still present in Kaliningrad’s Yantarny mines. Mostly, ambers are available in a light-yellow color, but can also find other variants with a dark brownish tinge or may have hues of dark green, dark blue, and white. Amber may be both transparent and opaque with tiny air bubbles inside it. While the most valued form of amber is the one that still has traces of organic life, & the oldest amber with an organism inside has mites and is from 230 million years ago in northeastern Italy. Pieces of plants can help identify the source of the amber and insects and other creatures are often perfected and preserved which gives information about them.

Amber is organic and its structure is highly amorphous. Since there’s no proper internal atomic arrangement in amber, one cannot call it a mineral. It is better defined as a gemstone. The specific gravity of amber is extremely low, making it one of the lightest stones available, which is why it will float in water with a higher density of saltwater. Amber as a perfume ingredient first made its debut in the late 1800s, with the invention of synthetic vanilla (vanillin), which is so widely used in amber-style perfumes nowadays. The resin has very little scent unless burned when it then gives off a pine-like aroma. For a more accepted and natural amber, labdanum absolute, a plant-based resin that carries ambery notes is more commonly used in perfumery. Benzoin resin is another ingredient that recreates an amber aroma with Smokey balsamic notes.

Amber in Perfumes

Amber is synonymous with the oriental family & is often used as a base note in premium perfumes and candle fragrances, which is mystical, elusive, and exotic. the smell of amber is made from a combination of other scents — not the fossilized resin, which has little to no scent on its own.  There is no standard formulation for the smell of amber, but a sweet, resinous, cozy, and warm, often rather powdery note is recreated from a mix of balsams, usually labdanum, benzoin, vanilla, styrax, and fir, or a combination of some of these. As an incredibly versatile base note, amber can be combined with a variety of floral, fruity, and citrusy scents to add depth and roundness, making it a common yet elusive scent in the fragrance world…!

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Leather in Perfumes

Perfumes & leather have been inseparable, historically.  The link between these dates to about 2000 years before the birth of Christ. During that period, in Asia, perfumes were created by rubbing the leather with the bark from fragrant trees like kumquat, whereas later in Spain skins were treated with diverse scents such as earthy musk, amber, or sharp savory camphor, while in Italy they perfumed their leather scent with sweet aspects of almondiris or civet.

During the period of the Renaissance, leather becomes a symbol of wealth & pride, which made people spend an enormous amount to buy the most attractive tanned items, especially gloves. The tanners were mostly settled in the provincial Grasse in France, & so there was a brisk trade between them and buyers from Italy, mainly Genoa and Pisa. The 16th-century Florentine noblewoman Catherine de Medici received a pair of perfumed leather gloves from the tanner Monsieur Molinard during a visit to Grasse, with which she was delighted with this fragrant keepsake. The perfume he had used to mask the scent of the leather was a blend of lavender, orange blossom, plants, and flowers from the area. This introduced the perfumed glove to France and the corporation of glovers-perfumers was created until its dissolution in 1759. By this century, Italian leather also marked its beginning, which was perfumed with a base of almonds, among other things, and was a discovery made by Marquis Pompeo Frangipani.

In Spain, the leather was also perfumed with a mixture of herbal and flower oils, and a scent known as Peau d’Espagne (the skin of Spain) was born. In the 19th century, Leather and the art of perfumery spread from France to Russia, where it was customary for dancers and soldiers to polish the leather shoes waterproof with fragrant essences such as birch tar, styrax, tarred scents, and notes of spicy licorice and herbaceous and slightly mossy tobacco as well.! This development led to the creation of Guerlain’s Cuir de Russie in 1872, and many other well-known houses would market their own ‘Cuir de Russie’, which was eventually launched as a separate fragrance family.

Earlier to bring a leather facet to a composition, birch tar oil was used. The Tar, or birch pitch, is a substance that is hermetically created by heating birch bark, & obtains a pasty substance composed of tar and ashes from the bark. In perfumery, this birch tar essence is obtained by long dry steam distillation of this substance. This essence evokes the olfactory sensation of a wood fire, with warm and smoky notes. Instead of birch bark, Cade essence can also be used. This tree also called cade juniper, grows mainly in the coastal regions of the Mediterranean, from Morocco to Iran. An essence with a very powerful smoky scent is created with its distilled wood and roots. The essence of agar, the main constituent of oud wood, can also be used to create leathery notes.

Nowadays leather accord is created in several ways, with birch tar, castoreum, styrax, oud, labdanum, quinolines, or synthetic accords., along with some flowers which also have leathery facets, particularly warm, honeyed, and balsamic cassia.

The fragrance family of leather is Woody with the leather perfumes, apt for everyone, and so this fragrance family is equally loved by both men and women. Tough, elegant, animalistic, or seductive: everything is possible. The leathery olfactory family has an atypical scent that reproduces the notes & can take on different facets: smoky, tarry, burnt, or even shades of tobacco. A leathery note in a perfume renders a unique touch to any fragrance because it evokes potent associations, revealing itself as silky facets that render the sensation of floral and apricot tones, while vegetable leather is making its way into the world of textiles.